Correlates of low hemoglobin A1c in maintenance hemodialysis patients.

ABSTRACT:

Purpose

The optimal target for glycemic control has not been established for diabetic maintenance hemodialysis (MHD) patients.

Methods

A 6-year cohort (October 2001- December 2006) of 347 diabetic MHD patients with HbA1c data was examined for associations between HbA1c and mortality. Death hazard ratios (HR) were estimated using Cox regressions and cubic splines.

Results

In these 347 patients (age, 59 ± 11 years; 49 % women; 28 % African Americans; and 55 % Hispanics), each 0.5 % decline in HbA1c below 6 % was associated with a 4.7 times higher death risk (HR = 4.7; 95 % CI 1.7-12.7) in the fully adjusted model. Factors associated with lower HbA1c levels (<6 % compared to 6-7 %) were: Hispanic ethnicity (OR = 2.9; 95 % CI 1.1-7.9), higher mid-arm muscle circumstance (

SUBMITTER: Kim Y 

PROVIDER: S-EPMC4326056 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature