Betamethasone in pregnancy: influence of maternal body weight and multiple gestation on pharmacokinetics.

ABSTRACT:

Objective

The goals of the study were to estimate the pharmacokinetic parameters of standard dose betamethasone in a large obstetrics population and evaluate the effect of maternal body size and multiple gestation on the pharmacokinetic parameters and their observed variability.

Study design

This was a prospective pharmacokinetic study. Liquid chromatography mass spectrometry was used to measure betamethasone plasma concentrations. Pharmacokinetic parameters and significant clinical covariates were estimated with mixed effect modeling. Bootstrap analysis confirmed validity of the model.

Results

Two hundred seventy-four blood samples from 77 patients were obtained. The greatest effect on pharmacokinetic variability was observed with maternal lean body weight (LBW). The

SUBMITTER: Della Torre M 

PROVIDER: S-EPMC4326076 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature