Synthesis and click chemistry of a new class of biodegradable polylactide towards tunable thermo-responsive biomaterials.

ABSTRACT: A new class of clickable and biodegradable polylactide was designed and prepared via bulk polymerization of 3,6-dipropargyloxymethyl-1,4-dioxane-2,5-dione (1) which was synthesized from easily accessible propargyloxylactic acid (5). A homopolymer of 1 and random copolymer of 1 with l-lactide were obtained as amorphous materials and exhibit low T_g of 8.5 and 34 °C, respectively, indicating their promising potentials for biomedical applications. The statistical nature of random copolymers was investigated by DSC analysis and ¹³C NMR spectroscopy, which implies the random distribution of terminal alkyne groups along the back bone of copolymers. The efficient click post-modification of this new class of polylactide with alkyl and

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC4326109 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature