ARID1A expression in gastric adenocarcinoma: clinicopathological significance and correlation with DNA mismatch repair status.

ABSTRACT:

Aim

To analyze the mismatch repair (MMR) status and the ARID1A expression as well as their clinicopathological significance in gastric adenocarcinomas.

Methods

We examined the expressions of MMR proteins and ARID1A by immunohistochemistry in consecutive 489 primary gastric adenocarcinomas. The results were further correlated with clinicopathological variables.

Results

The loss of any MMR protein expression, indicative of MMR deficiency, was observed in 38 cases (7.8%) and was significantly associated with an older age (68.6±9.2 vs 60.4±11.7, P<0.001), a female sex (55.3% vs 31.3%, P=0.004), an antral location (44.7% vs 25.7%, P=0.021), and a differentiated histology (57.9% vs 39.7%, P=0.023). Abnormal ARID1A expression, including reduced or loss of ARID1A expression,

SUBMITTER: Inada R 

PROVIDER: S-EPMC4326154 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature