Conformational B-cell epitope prediction method based on antigen preprocessing and mimotopes analysis.

ABSTRACT: Identification of epitopes which invokes strong humoral responses is an essential issue in the field of immunology. Various computational methods that have been developed based on the antigen structures and the mimotopes these years narrow the search for experimental validation. These methods can be divided into two categories: antigen structure-based methods and mimotope-based methods. Though new methods of the two kinds have been proposed in these years, they cannot maintain a high degree of satisfaction in various circumstances. In this paper, we proposed a new conformational B-cell epitope prediction method based on antigen preprocessing and mimotopes analysis. The method classifies the antigen surface residues into "epitopes" and "nonepitopes" by six epitope propensity scales, removin

SUBMITTER: Sun P 

PROVIDER: S-EPMC4326220 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature