Genetically adjusted prostate-specific antigen values may prevent delayed biopsies in African-American men.

ABSTRACT:

Objective

To evaluate whether genetic correction using the genetic variants prostate-specific antigen (PSA)-single nucleotide polymorphisms (SNPs) could reduce potentially unnecessary and/or delayed biopsies in African-American men.

Subjects and methods

We compared the genotypes of four PSA-SNPs between 964 Caucasian and 363 African-American men without known prostate cancer (PCa). We adjusted the PSA values based on an individual's PSA-SNP carrier status, and calculated the percentage of men that would meet commonly used PSA thresholds for biopsy (≥ 2.5 or ≥ 4.0 ng/mL) before and after genetic correction. Potentially unnecessary and delayed biopsies were defined as those men who were below and above the biopsy threshold after genetic correction, respectively.

Results

SUBMITTER: Donin NM 

PROVIDER: S-EPMC4326233 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature