Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice.

ABSTRACT:

Background

In utero undernutrition is associated with obesity and insulin resistance, although its effects on skeletal muscle remain poorly defined. Therefore, in the current study we explored the effects of in utero food restriction on muscle energy metabolism in mice.

Methods

We used an experimental mouse model system of maternal undernutrition during late pregnancy to examine offspring from undernourished dams (U) and control offspring from ad libitum-fed dams (C). Weight loss of 10-week-old offspring on a 4-week 40% calorie-restricted diet was also followed. Experimental approaches included bioenergetic analyses in isolated mitochondria, intact (permeabilized) muscle and at the whole body level.

Results

U have increased adiposity and decreased glucose tolerance co

SUBMITTER: Beauchamp B 

PROVIDER: S-EPMC4326251 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature