Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection.

ABSTRACT:

Background

Despite effective antiretroviral therapy (ART), patients with chronic human immunodeficiency virus (HIV) infection have increased microbial translocation and systemic inflammation. Alterations in the intestinal microbiota may play a role in microbial translocation and inflammation.

Methods

We profiled the fecal microbiota by pyrosequencing the gene encoding 16S ribosomal RNA (rRNA) and measured markers of microbial translocation and systemic inflammation in 21 patients who had chronic HIV infection and were receiving suppressive ART (cases) and 16 HIV-uninfected controls.

Results

The fecal microbial community composition was significantly different between cases and controls. The relative abundance of Proteobacteria, Gammaproteobacteria, Enterobacteriales,

SUBMITTER: Dinh DM 

PROVIDER: S-EPMC4326316 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature