Spatial features for Escherichia coli genome organization.

ABSTRACT:

Background

In bacterial genomes, the compactly encoded genes and operons are well organized, with genes in the same biological pathway or operons in the same regulon close to each other on the genome sequence. In addition, the linearly close genes have a higher probability of co-expression and their protein products tend to form protein-protein interactions. However, the organization features of bacterial genomes in a three-dimensional space remain elusive. The DNA interaction data of Escherichia coli, measured by the genome conformation capture (GCC) technique, have recently become available, which allowed us to investigate the spatial features of bacterial genome organization.

Results

By renormalizing the GCC data, we compared the interaction frequency of operon pairs in t

SUBMITTER: Xie T 

PROVIDER: S-EPMC4326437 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature