Calibration of an intrahost malaria model and parameter ensemble evaluation of a pre-erythrocytic vaccine.

ABSTRACT:

Background

A pre-erythrocytic vaccine could provide a useful tool for burden reduction and eventual eradication of malaria. Mathematical malaria models provide a mechanism for evaluating the effective burden reduction across a range of transmission conditions where such a vaccine might be deployed.

Methods

The EMOD model is an individual-based model of malaria transmission dynamics, including vector lifecycles and species-specific behaviour, coupled to a mechanistic intrahost model of malaria parasite and host immune system dynamics. The present work describes the extension of the EMOD model to include diagnoses of severe malaria and iterative calibration of the immune system parameters and parasite antigenic variation to age-stratified prevalence, incidence and severe disea

SUBMITTER: McCarthy KA 

PROVIDER: S-EPMC4326442 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature