Erythropoietin in traumatic brain injury: study protocol for a randomised controlled trial.

ABSTRACT:

Background

Traumatic brain injury is a leading cause of death and disability worldwide. Laboratory and clinical studies demonstrate a possible beneficial effect of erythropoietin in improving outcomes in the traumatic brain injury cohort. However, there are concerns regarding the association of erythropoietin and thrombosis in the critically ill. A large-scale, multi-centre, blinded, parallel-group, placebo-controlled, randomised trial is currently underway to address this hypothesis.

Methods/design

The erythropoietin in traumatic brain injury trial is a stratified prospective, multi-centre, randomised, blinded, parallel-group, placebo-controlled phase III trial. It aims to determine whether the administration of erythropoietin compared to placebo improves neurological outco

SUBMITTER: Nichol A 

PROVIDER: S-EPMC4326467 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature