Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.

ABSTRACT: Over recent years, accumulated evidence suggests that autophagy induction is protective in animal models of a number of neurodegenerative diseases. Intense research in the field has elucidated different pathways through which autophagy can be upregulated and it is important to establish how modulation of these pathways impacts upon disease progression in vivo and therefore which, if any, may have further therapeutic relevance. In addition, it is important to understand how alterations in these target pathways may affect normal physiology when constitutively modulated over a long time period, as would be required for treatment of neurodegenerative diseases. Here we evaluate the potential protective effect of downregulation of calpains. We demonstrate, in Drosophila, that calpain knockdown p

SUBMITTER: Menzies FM 

PROVIDER: S-EPMC4326573 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature