Long-term use of antibiotics and proton pump inhibitors predict development of infections in patients with cirrhosis.

ABSTRACT:

Background & aims

Bacterial infections, particularly repeated infections, are significant causes of morbidity and mortality among patients with cirrhosis. We investigated and characterized risk factors for repeat infections in these patients.

Methods

In a prospective study, we collected data from 188 patients hospitalized with cirrhosis and infections and enrolled in the North American Consortium for the Study of End-Stage Liver Disease (12 centers). Patients were followed up for 6 months after hospital discharge and data were analyzed on type of infections and factors associated with subsequent infections.

Results

Six months after hospital discharge, 14% of subjects had received liver transplants, 27% died, and 59% were alive without liver transplantation. After disc

SUBMITTER: O'Leary JG 

PROVIDER: S-EPMC4326601 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature