Ontology highlight
ABSTRACT:
SUBMITTER: Carroll PA
PROVIDER: S-EPMC4326605 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cancer cell 20150129 2
Deregulated Myc transcriptionally reprograms cell metabolism to promote neoplasia. Here we show that oncogenic Myc requires the Myc superfamily member MondoA, a nutrient-sensing transcription factor, for tumorigenesis. Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc-induced reprogramming of multiple metabolic pathways, resulting in apoptosis. Identification and knockdown of genes coregulated by Myc and MondoA have allowed us to define metabolic functions required by deregulated ...[more]