Processive pulses of retinoic acid propel asynchronous and continuous murine sperm production.

ABSTRACT: The asynchronous cyclic nature of spermatogenesis is essential for continual sperm production and is one of the hallmarks of mammalian male fertility. While various mRNA and protein localization studies have indirectly implicated changing retinoid levels along testis tubules, no quantitative evidence for these changes across the cycle of the seminiferous epithelium currently exists. This study utilized a unique mouse model of induced synchronous spermatogenesis, localization of the retinoid-signaling marker STRA8, and sensitive quantification of retinoic acid concentrations to determine whether there are fluctuations in retinoid levels at each of the individual stages of germ cell differentiation and maturation to sperm. These data show that processive pulses of retinoic acid are generated

SUBMITTER: Hogarth CA 

PROVIDER: S-EPMC4326729 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature