Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis.

ABSTRACT: Senescent cells secrete a plethora of factors with potent paracrine signaling capacity. Strikingly, senescence, which acts as defense against cell transformation, exerts pro-tumorigenic activities through its secretome by promoting tumor-specific features, such as cellular proliferation, epithelial-mesenchymal transition and invasiveness. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the unique activity of activating cell death exclusively in tumor cells. Given that the senescence-associated secretome (SAS) supports cell transformation, we asked whether SAS factor(s) would establish a program required for the acquisition of TRAIL sensitivity. We found that conditioned media from several types of senescent cells (CMS) efficiently sensitized pretransformed cells to TRAI

SUBMITTER: Vjetrovic J 

PROVIDER: S-EPMC4326894 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature