Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet.

ABSTRACT: Recent discoveries have revealed the key role of mTOR (target of rapamycin) in aging. Furthermore, rapamycin extends lifespan in mice, especially in female mice. Here, we treated obese male mice on high-fat diet with rapamycin given intermittently: either weekly (once a week) or alternating bi-weekly (three injections every other week). While only marginally reducing obesity, intermittent administration of rapamycin significantly extended lifespan. Significance was achieved for weekly treated group and for the three rapamycin-received groups combined. In weekly treatment group, 100% mice were alive by the age of 2 years, whereas 60% of mice died in untreated group by this age. The effect of weekly treatment on survival was highly significant and cannot be fully explained by partial reducti

SUBMITTER: Leontieva OV 

PROVIDER: S-EPMC4326934 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature