Identification and characterization of a compound from Cuminum cyminum essential oil with antifibrilation and cytotoxic effect.

ABSTRACT: Amyloid pathology is associated with fibril aggregation of different proteins which results in the progressive damage of affected organs. It is strongly believed that specific small molecules interfere with fibrillation by interacting with the amyloidogenic proteins. We had previously reported the strong and long-term inhibition of fibrillation of hen egg white lysozyme (HEWL) by Cuminum cyminum oil. Herein, it was intended to rationally identify the active anti-amyloidogenic compounds of the oil. After fractionation, the highest inhibitory effect was observed in the toluene-ethyl acetate part of the oil. Gas chromatography-mass spectrometry (GC-MS) analysis of this fraction indicated that eight compounds were predominantly present in the fraction. Unexpectedly, two compounds including ter

SUBMITTER: Morshedi D 

PROVIDER: S-EPMC4326981 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature