Association between polymorphism in the promoter region (G/C-915) of PAX9 gene and third molar agenesis.

ABSTRACT:

Purpose

Hypodontia is the congenital absence of one or more (up to six) permanent and/or deciduous teeth, being one of the most common alterations of the human dentition. Genetic polymorphisms are variations of DNA sequences occurring in a population. This study investigated whether G-915C single nucleotide polymorphism (SNPs) in the PAX9 gene promoter is associated with hypodontia in humans.

Material and methods

The polymorphism in region G/C-915 of PAX9 gene (NCBI ref SNP ID: rs 2073247) of 240 patients was analyzed, being 110 controls and 130 individuals with third molar agenesis. After DNA extraction, the region of interest was amplified by PCR technique using two different primers. The significance of the differences in observed frequencies of polymorphisms in both grou

SUBMITTER: Bianch FJ 

PROVIDER: S-EPMC4327256 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature