Condition interference in rats performing a choice task with switched variable- and fixed-reward conditions.

ABSTRACT: Because humans and animals encounter various situations, the ability to adaptively decide upon responses to any situation is essential. To date, however, decision processes and the underlying neural substrates have been investigated under specific conditions; thus, little is known about how various conditions influence one another in these processes. In this study, we designed a binary choice task with variable- and fixed-reward conditions and investigated neural activities of the prelimbic cortex and dorsomedial striatum in rats. Variable- and fixed-reward conditions induced flexible and inflexible behaviors, respectively; one of the two conditions was randomly assigned in each trial for testing the possibility of condition interference. Rats were successfully conditioned such that they c

SUBMITTER: Funamizu A 

PROVIDER: S-EPMC4327310 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature