Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway.

ABSTRACT: Some patients with soft-tissue sarcoma (STS) report a history of injury at the site of their tumor. Although this phenomenon is widely reported, there are relatively few experimental systems that have directly assessed the role of injury in sarcoma formation. We recently described a mouse model of STS whereby p53 is deleted and oncogenic Kras is activated in muscle satellite cells via a Pax7(CreER) driver following intraperitoneal injection with tamoxifen. Here, we report that after systemic injection of tamoxifen, the vast majority of Pax7-expressing cells remain quiescent despite mutation of p53 and Kras. The fate of these muscle progenitors is dramatically altered by tissue injury, which leads to faster kinetics of sarcoma formation. In adult muscle, quiescent satellite cells will trans

SUBMITTER: Van Mater D 

PROVIDER: S-EPMC4327867 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature