Differential expression of pancreatitis-associated protein and thrombospondins in arterial versus venous tissues.

ABSTRACT:

Background/aims

Arteries and veins modulate cardiovascular homeostasis and contribute to hypertension pathogenesis. Functional differences between arteries and veins are based upon differences in gene expression. To better characterize these expression patterns, and to identify candidate genes that could be manipulated selectively in the venous system, we performed whole genome expression profiling of arteries and veins.

Methods

We used the CodeLink platform and the major artery (thoracic aorta) and vein (caudal vena cava) of the rat.

Results

The most prominent difference was pancreatitis-associated protein (PAP1), expressed 64-fold higher in vena cava versus aorta. Expression of mRNA for thrombospondins (TSP-1, TSP-4) was greater than 5-fold higher in veins versus ar

SUBMITTER: Szasz T 

PROVIDER: S-EPMC4327871 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature