Mutational analysis and clinical correlation of metastatic colorectal cancer.

ABSTRACT:

Background

Early identification of mutations may guide patients with metastatic colorectal cancer toward targeted therapies that may be life prolonging. The authors assessed tumor genotype correlations with clinical characteristics to determine whether mutational profiling can account for clinical similarities, differences, and outcomes.

Methods

Under Institutional Review Board approval, 222 patients with metastatic colon adenocarcinoma (n = 158) and rectal adenocarcinoma (n = 64) who underwent clinical tumor genotyping were reviewed. Multiplexed tumor genotyping screened for >150 mutations across 15 commonly mutated cancer genes. The chi-square test was used to assess genotype frequency by tumor site and additional clinical characteristics. Cox multivariate analysis was use

SUBMITTER: Russo AL 

PROVIDER: S-EPMC4327902 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature