Laminar Tendon Composites with Enhanced Mechanical Properties.

ABSTRACT: PURPOSE:A strong isotropic material that is both biocompatible and biodegradable is desired for many biomedical applications, including rotator cuff repair, tendon and ligament repair, vascular grafting, among others. Recently, we developed a technique, called "bioskiving" to create novel 2D and 3D constructs from decellularized tendon, using a combination of mechanical sectioning, and layered stacking and rolling. The unidirectionally aligned collagen nanofibers (derived from sections of decellularized tendon) offer good mechanical properties to the constructs compared with those fabricated from reconstituted collagen. METHODS:In this paper, we studied the effect that several variables have on the mechanical properties of structures fabricated from tendon slices, including crosslinking de

SUBMITTER: Alberti KA 

PROVIDER: S-EPMC4327911 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature