A prospective feasibility study of respiratory-gated proton beam therapy for liver tumors.

ABSTRACT:

Purpose

To evaluate the feasibility of a respiratory-gated proton beam therapy for liver tumors.

Methods and materials

Fifteen patients were enrolled in a prospective institutional review board-approved protocol. Eligibility criteria included Childs-Pugh A/B cirrhosis, unresectable biopsy- proven hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), or metastatic disease (solid tumors only), 1-3 lesions, and tumor size of ≤6 cm. Patients received 15 fractions to a total dose of 45-75 GyE [gray equivalent] using respiratory-gated proton beam therapy. Gating was performed with an external respiratory position monitoring based system.

Results

Of the 15 patients enrolled in this clinical trial, 11 had HCC, 3 had ICC, and 1 had metastasis from another prim

SUBMITTER: Hong TS 

PROVIDER: S-EPMC4327929 | biostudies-literature | 2014 Sep-Oct

REPOSITORIES: biostudies-literature