Epidermolysis bullosa in Danish Hereford calves is caused by a deletion in LAMC2 gene.

ABSTRACT:

Background

Heritable forms of epidermolysis bullosa (EB) constitute a heterogeneous group of skin disorders of genetic aetiology that are characterised by skin and mucous membrane blistering and ulceration in response to even minor trauma. Here we report the occurrence of EB in three Danish Hereford cattle from one herd.

Results

Two of the animals were necropsied and showed oral mucosal blistering, skin ulcerations and partly loss of horn on the claws. Lesions were histologically characterized by subepidermal blisters and ulcers. Analysis of the family tree indicated that inbreeding and the transmission of a single recessive mutation from a common ancestor could be causative. We performed whole genome sequencing of one affected calf and searched all coding DNA variants. Ther

SUBMITTER: Murgiano L 

PROVIDER: S-EPMC4328060 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature