A putative placebo analysis of the effects of LCZ696 on clinical outcomes in heart failure.

ABSTRACT:

Aims

Although active-controlled trials with renin–angiotensin inhibitors are ethically mandated in heart failure with reduced ejection fraction, clinicians and regulators often want to know how the experimental therapy would perform compared with placebo. The angiotensin receptor-neprilysin inhibitor LCZ696 was compared with enalapril in PARADIGM-HF. We made indirect comparisons of the effects of LCZ696 with putative placebos.

Methods and results

We used the treatment-arm of the Studies Of Left Ventricular Dysfunction (SOLVD-T) as the reference trial for comparison of an ACE inhibitor to placebo and the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity-Alternative trial (CHARM-Alternative) as the reference trial for comparison of an ARB to plac

SUBMITTER: McMurray J 

PROVIDER: S-EPMC4328198 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature