Gene coexpression networks reveal key drivers of phenotypic divergence in porcine muscle.

ABSTRACT:

Background

Domestication of the wild pig has led to obese and lean phenotype breeds, and evolutionary genome research has sought to identify the regulatory mechanisms underlying this phenotypic diversity. However, revealing the molecular mechanisms underlying muscle phenotype variation based on differentially expressed genes has proved to be difficult. To characterize the mechanisms regulating muscle phenotype variation under artificial selection, we aimed to provide an integrated view of genome organization by weighted gene coexpression network analysis.

Results

Our analysis was based on 20 publicly available next-generation sequencing datasets of lean and obese pig muscle generated from 10 developmental stages. The evolution of the constructed coexpression modules was exam

SUBMITTER: Zhao X 

PROVIDER: S-EPMC4328970 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature