Fecal microbial transplant effect on clinical outcomes and fecal microbiome in active Crohn's disease.

ABSTRACT:

Background

Crohn's disease (CD) is a chronic idiopathic inflammatory intestinal disorder associated with fecal dysbiosis. Fecal microbial transplant (FMT) is a potential therapeutic option for individuals with CD based on the hypothesis that changing the fecal dysbiosis could promote less intestinal inflammation.

Methods

Nine patients, aged 12 to 19 years, with mild-to-moderate symptoms defined by Pediatric Crohn's Disease Activity Index (PCDAI of 10-29) were enrolled into a prospective open-label study of FMT in CD (FDA IND 14942). Patients received FMT by nasogastric tube with follow-up evaluations at 2, 6, and 12 weeks. PCDAI, C-reactive protein, and fecal calprotectin were evaluated at each study visit.

Results

All reported adverse events were graded as mild excep

SUBMITTER: Suskind DL 

PROVIDER: S-EPMC4329080 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature