Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation.

ABSTRACT:

Rationale

Depletion of medial smooth muscle cell (SMC) is a major pathological characteristic of abdominal aortic aneurysm (AAA), although the mechanism by which these cells are eliminated remains incompletely understood. We reasoned that necroptosis, a recently described form of necrosis mediated by receptor-interacting protein kinase 3 (RIP3), may contribute to AAA pathology through the induction of SMC death and the significant production of inflammatory cytokines.

Objective

To test the hypothesis that RIP3-mediated necroptosis is actively involved in aneurysm pathogenesis.

Methods and results

RIP3 and RIP1 levels were found to be elevated in human AAAs, most noticeably in SMCs. Elevations of RIP3 and SMC necrosis were also observed in the elastase-induced mouse mo

SUBMITTER: Wang Q 

PROVIDER: S-EPMC4329096 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature