Ontology highlight
ABSTRACT:
SUBMITTER: Freund A
PROVIDER: S-EPMC4329143 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Cell 20141120 6
Telomere maintenance by telomerase is impaired in the stem cell disease dyskeratosis congenita and during human aging. Telomerase depends upon a complex pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres. Here, we identify the chaperonin CCT/TRiC as a critical regulator of telomerase trafficking using a high-content genome-wide siRNA screen in human cells for factors required for Cajal body localization. We find that TRiC is required for folding the telomer ...[more]