S gene mutants occurrence among hepatitis B carriers in malaysia.

ABSTRACT:

Background

The S gene region of the hepatitis B virus (HBV) codes for surface antigen (HBs Ag) and is responsible for classification of HBV strains.

Objectives

The current study aimed to identify important mutations in the S gene in Hepatitis B virus (HBV) isolated from Malaysian HBV carriers.

Materials and methods

Isolated HBV DNAs were subjected for PCR amplification and sequencing of HBV full genome.

Results

A total of 76 HBV full genome and 17 partial genome sequences were obtained from the 93 sequenced sera samples Genotyping of the full genome sequences by HEPSEQ software revealed a distribution of 49.46%, 48.39% and 2.15% of genotypes C, B, and D, respectively; whereas phylogenetic and jumping profile Hidden Markov Model (jpHMM) analysis identified six (

SUBMITTER: Suppiah J 

PROVIDER: S-EPMC4329239 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature