An epidemiological perspective of personalized medicine: the Estonian experience.

ABSTRACT: The Estonian Biobank and several other biobanks established over a decade ago are now starting to yield valuable longitudinal follow-up data for large numbers of individuals. These samples have been used in hundreds of different genome-wide association studies, resulting in the identification of reliable disease-associated variants. The focus of genomic research has started to shift from identifying genetic and nongenetic risk factors associated with common complex diseases to understanding the underlying mechanisms of the diseases and suggesting novel targets for therapy. However, translation of findings from genomic research into medical practice is still lagging, mainly due to insufficient evidence of clinical validity and utility. In this review, we examine the different elements requi

SUBMITTER: Milani L 

PROVIDER: S-EPMC4329410 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature