Plasmodium berghei infection ameliorates atopic dermatitis-like skin lesions in NC/Nga mice.

ABSTRACT:

Background

Atopic diseases are more prevalent in industrialized countries than in developing countries. In addition, significant differences in the prevalence of allergic diseases are observed between rural and urban areas within the same country. This difference in prevalence has been attributed to what is called the 'hygiene hypothesis'. Although parasitic infections are known to protect against allergic reactions, the mechanism is still unknown. The aim of this study was to investigate whether or not malarial infections can inhibit atopic dermatitis (AD)-like skin lesions in a mouse model of AD.

Methods

We used NC/Nga mice which are a model for AD. The NC/Nga mice were intraperitoneally infected with 1 × 10(5) Plasmoduim berghei (Pb) XAT-infected erythrocytes.

Results<

SUBMITTER: Kishi C 

PROVIDER: S-EPMC4329412 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature