An integrative analysis of TFBS-clustered regions reveals new transcriptional regulation models on the accessible chromatin landscape.

ABSTRACT: DNase I hypersensitive sites (DHSs) define the accessible chromatin landscape and have revolutionised the discovery of distinct cis-regulatory elements in diverse organisms. Here, we report the first comprehensive map of human transcription factor binding site (TFBS)-clustered regions using Gaussian kernel density estimation based on genome-wide mapping of the TFBSs in 133 human cell and tissue types. Approximately 1.6 million distinct TFBS-clustered regions, collectively spanning 27.7% of the human genome, were discovered. The TFBS complexity assigned to each TFBS-clustered region was highly correlated with genomic location, cell selectivity, evolutionary conservation, sequence features, and functional roles. An integrative analysis of these regions using ENCODE data revealed transcriptio

SUBMITTER: Chen H 

PROVIDER: S-EPMC4329551 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature