Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans.

ABSTRACT:

Background

COPD patients have a great burden of comorbidity. However, it is not well established whether this is due to shared risk factors such as smoking, if they impact patients exercise capacity and quality of life, or whether there are racial disparities in their impact on COPD.

Methods

We analyzed data from 10,192 current and ex-smokers with (cases) and without COPD (controls) from the COPDGene® cohort to establish risk for COPD comorbidities adjusted for pertinent covariates. In adjusted models, we examined comorbidities prevalence and impact in African-Americans (AA) and Non-Hispanic Whites (NHW).

Results

Comorbidities are more common in COPD compared to those with normal spirometry (controls), and the risk persists after adjustments for covariates incl

SUBMITTER: Putcha N 

PROVIDER: S-EPMC4329763 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature