Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function.

ABSTRACT: Neurotrophins play a crucial role in mediating neuronal survival and synaptic plasticity. A lack of trophic factor support in the peripheral nervous system (PNS) is associated with a transcription-dependent programmed cell death process in developing sympathetic neurons. While most of the attention has been on events culminating in cell death in the PNS, the earliest events that occur after trophic factor withdrawal in the central nervous system (CNS) have not been investigated. In the CNS, brain-derived neurotrophic factor (BDNF) is widely expressed and is released in an activity-dependent manner to shape the structure and function of neuronal populations. Reduced neurotrophic factor support has been proposed as a mechanism to account for changes in synaptic plasticity during neurodevelop

SUBMITTER: Mariga A 

PROVIDER: S-EPMC4329925 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature