Resting heart rate and risk of incident heart failure: three prospective cohort studies and a systematic meta-analysis.

ABSTRACT:

Background

The relationship between resting heart rate (RHR) and incident heart failure (HF) has been questioned.

Methods and results

RHR was assessed at baseline in 7073 participants in 3 prospective cohorts (Cardiovascular Health Study, Health ABC study and Kuopio Ischemic Heart Disease Study) that recorded 1189 incident HF outcomes during 92 702 person-years of follow-up. Mean age of participants was 67 (9.9) years and mean RHR was 64.6 (11.1) bpm. Baseline RHR correlated (P<0.001) positively with body mass index (r=0.10), fasting glucose (r=0.18), and C-reactive protein (r=0.20); and inversely with serum creatinine (r=-0.05) and albumin (r=-0.05). Baseline RHR was non-linearly associated with HF risk. The age and sex-adjusted hazard ratio for HF comparing the top (>72 bp

SUBMITTER: Khan H 

PROVIDER: S-EPMC4330063 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature