Interactive effect of smoking and NQO1 haplotypes on lung cancer risk.

ABSTRACT: The role of genetic polymorphisms of

Nad(p)h

quinone oxidoreductase 1 (NQO1), which is known to be related to carcinogen metabolism and oxidative status, was evaluated for lung cancer development. The genotypes of two NQO1 polymorphisms, namely, IVS1-27C>G and Ex6+40C>T, were determined in 616 lung cancer cases and 616 lung cancer-free controls and haplotypes composed of the two polymorphisms were estimated. In the evaluation of the effect of the NQO1 genotypes or diplotypes, we did not find any significant association with lung cancer risk after adjusting for body mass index and smoking status. However, when we evaluated the effect of the NQO1 diplotypes for lung cancer risk in combination with smoking, smokers without the C-T/C-T diplotype showed a significantly increased risk of

SUBMITTER: Kim JH 

PROVIDER: S-EPMC4330473 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature