The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates.

ABSTRACT:

Background

Dinoflagellates are eukaryotes with unusual cell biology and appear to rely on translational rather than transcriptional control of gene expression. The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in regulating gene expression because eIF4E binding to the mRNA cap is a control point for translation. eIF4E is part of an extended, eukaryote-specific family with different members having specific functions, based on studies of model organisms. Dinoflagellate eIF4E diversity could provide a mechanism for dinoflagellates to regulate gene expression in a post-transcriptional manner. Accordingly, eIF4E family members from eleven core dinoflagellate transcriptomes were surveyed to determine the diversity and phylogeny of the eIF4E family in dinofla

SUBMITTER: Jones GD 

PROVIDER: S-EPMC4330643 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature