Chemodetection in fluctuating environments: receptor coupling, buffering, and antagonism.

ABSTRACT: Variability in the chemical composition of the extracellular environment can significantly degrade the ability of cells to detect rare cognate ligands. Using concepts from statistical detection theory, we formalize the generic problem of detection of small concentrations of ligands in a fluctuating background of biochemically similar ligands binding to the same receptors. We discover that in contrast with expectations arising from considerations of signal amplification, inhibitory interactions between receptors can improve detection performance in the presence of substantial environmental variability, providing an adaptive interpretation to the phenomenon of ligand antagonism. Our results suggest that the structure of signaling pathways responsible for chemodetection in fluctuating and het

SUBMITTER: Lalanne JB 

PROVIDER: S-EPMC4330740 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature