Effects of surgical and dietary weight loss therapy for obesity on gut microbiota composition and nutrient absorption.

ABSTRACT: Evidence suggests a correlation between the gut microbiota composition and weight loss caused by caloric restriction. Laparoscopic sleeve gastrectomy (LSG), a surgical intervention for obesity, is classified as predominantly restrictive procedure. In this study we investigated functional weight loss mechanisms with regard to gut microbial changes and energy harvest induced by LSG and a very low calorie diet in ten obese subjects (n = 5 per group) demonstrating identical weight loss during a follow-up period of six months. For gut microbiome analysis next generation sequencing was performed and faeces were analyzed for targeted metabolomics. The energy-reabsorbing potential of the gut microbiota decreased following LSG, indicated by the Bacteroidetes/Firmicutes ratio, but increased during d

SUBMITTER: Damms-Machado A 

PROVIDER: S-EPMC4330959 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature