Ontology highlight
ABSTRACT:
SUBMITTER: Van Praet JT
PROVIDER: S-EPMC4331001 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20150119 4
Antinuclear antibodies are a hallmark feature of generalized autoimmune diseases, including systemic lupus erythematosus and systemic sclerosis. However, the processes underlying the loss of tolerance against nuclear self-constituents remain largely unresolved. Using mice deficient in lymphotoxin and Hox11, we report that approximately 25% of mice lacking secondary lymphoid organs spontaneously develop specific antinuclear antibodies. Interestingly, we find this phenotype is not caused by a defe ...[more]