Safety of cotrimoxazole in pregnancy: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Cotrimoxazole is widely prescribed to treat a range of infections, and for HIV-infected individuals it is administered as prophylaxis to protect against opportunistic infections. Some reports suggest that fetuses exposed to cotrimoxazole during early pregnancy may have an increased risk of congenital anomalies. We carried out this systematic review to update the evidence of cotrimoxazole safety in pregnancy.

Methods

Three databases and 1 conference abstract site were searched in duplicate up to October 31, 2013, for studies reporting adverse maternal and infant outcomes among women receiving cotrimoxazole during pregnancy. This search was updated in MEDLINE via PubMed to April 28, 2014. Studies were included irrespective of HIV infection status or the presence o

SUBMITTER: Ford N 

PROVIDER: S-EPMC4331013 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature