Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults.

ABSTRACT:

Importance

Epigenetic studies present unique opportunities to advance schizophrenia research because they can potentially account for many of its clinical features and suggest novel strategies to improve disease management.

Objective

To identify schizophrenia DNA methylation biomarkers in blood.

Design, setting, and participants

The sample consisted of 759 schizophrenia cases and 738 controls (N = 1497) collected in Sweden. We used methyl-CpG-binding domain protein-enriched genome sequencing of the methylated genomic fraction, followed by next-generation DNA sequencing. We obtained a mean (SD) number of 68 (26.8) million reads per sample. This massive data set was processed using a specifically designed data analysis pipeline. Critical top findings from our methylome-

SUBMITTER: Aberg KA 

PROVIDER: S-EPMC4331014 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature