Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.

ABSTRACT:

Background

Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population.

Methods

Using the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls.

Results

We conf

SUBMITTER: Yang SK 

PROVIDER: S-EPMC4331109 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature