Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging.

ABSTRACT: Calcium imaging is a versatile experimental approach capable of resolving single neurons with single-cell spatial resolution in the brain. Electrophysiological recordings provide high temporal, but limited spatial resolution, because of the geometrical inaccessibility of the brain. An approach that integrates the advantages of both techniques could provide new insights into functions of neural circuits. Here, we report a transparent, flexible neural electrode technology based on graphene, which enables simultaneous optical imaging and electrophysiological recording. We demonstrate that hippocampal slices can be imaged through transparent graphene electrodes by both confocal and two-photon microscopy without causing any light-induced artefacts in the electrical recordings. Graphene electrod

SUBMITTER: Kuzum D 

PROVIDER: S-EPMC4331185 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature