An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure andrographolide.

ABSTRACT:

Background

The anti-inflammatory activity of Andrographis paniculata (Acanthaceae), a traditional medicine widely used in Asia, is commonly attributed to andrographolide, its main secondary metabolite. Commercial A. paniculata extracts are standardised to andrographolide content. We undertook the present study to investigate 1) how selective enrichment of andrographolide in commercial A. paniculata extracts affects the variability of non-standardised phytochemical components and 2) if variability in the non-standardised components of the extract affects the pharmacological activity of andrographolide itself.

Methods

We characterized 12 commercial, standardised (≥30% andrographolide) batches of A. paniculata extracts from India by HPLC profiling. We determined the antioxidant

SUBMITTER: Low M 

PROVIDER: S-EPMC4331298 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature