A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.

ABSTRACT:

Background

Tenofovir disoproxil fumarate (TDF) is a widely used antiretroviral agent with favorable efficacy, safety, and tolerability profiles. However, renal adverse events, including the rare Fanconi syndrome (FS), may occur in a small subset of patients treated for HIV infections.

Objectives

The aim of this study was to identify genetic variants that may be associated with TDF-associated FS (TDF-FS).

Methods

DNA samples collected from 19 cases with TDF-FS and 36 matched controls were sequenced, and genetic association studies were conducted on eight candidate genes: ATP-binding cassette (ABC) transporters ABCC2 (MRP2) and ABCC4 (MRP4), solute carrier family members SLC22A6 (OAT1) and SLC22A8 (OAT3), adenylate kinases 2 (AK2) and 4 (AK4), chloride transporter CIC-5

SUBMITTER: Dahlin A 

PROVIDER: S-EPMC4331349 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature