Molecular insights into proton coupled peptide transport in the PTR family of oligopeptide transporters.

ABSTRACT:

Background

Cellular uptake of small peptides is an important physiological process mediated by the PTR family of proton-coupled peptide transporters. In bacteria peptides can be used as a source of amino acids and nitrogen. Similarly in humans peptide transport is the principle route for the uptake and retention of dietary protein in the form of short di- and tri-peptides for cellular metabolism.

Scope of the review

Recent crystal structures of bacterial PTR family transporters, combined with biochemical studies of transport have revealed key molecular details underpinning ligand promiscuity and the mechanism of proton-coupled transport within the family.

Major conclusions

Pairs of salt bridge interactions between transmembrane helices work in tandem to orchestrate al

SUBMITTER: Newstead S 

PROVIDER: S-EPMC4331665 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature